rs1307379746
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs141865425
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs13277113
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
rs13277113
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 x 10(-23)) and BLK (rs13277113, OR=0.77, P=1.34 x 10(-5)) with SLE.
|
19225526 |
2009 |
rs13277113
|
|
A |
0.890 |
GeneticVariation |
GWASDB |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In addition, we observed a genetic interaction between BLK (rs2736340T/C, rs13277113A/G) and BANK1 (R61H and A383T) associated with susceptibility to SLE.
|
31134304 |
2019 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
rs13277113
|
|
A |
0.890 |
GeneticVariation |
GWASDB |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Minor alleles of rs13277113 (P = 4.2E-05, odds ratio [OR] 0.66, [95% CI 0.54-0.81]) and rs4840568 (P = 7.1E-05, OR 0.67, [95% CI 0.55-0.82]) were found to be protective against SLE.
|
22313735 |
2012 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
On the assessment of available evidence, the authors concluded that moderate evidence exists for an association between the BLK rs13277113, rs2248932 variants and SLE.
|
21152986 |
2011 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
rs13277113
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Because both the risk allele frequency and the OR were higher in Japanese than in Caucasians, the PAR% of rs13277113 was estimated to be much higher in Japanese (35.4%) than in Caucasians (16.2%), and the second highest among the 6 confirmed SLE susceptibility genes in Japanese.
|
19180478 |
2009 |
rs2618476
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
|
19165918 |
2008 |
rs2618476
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
|
19165918 |
2008 |
rs2248932
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We confirmed that SNP rs2248932 in BLK gene was significantly associated with SLE (P = 1.41 x 10(-8) for the allele frequency, Odds ratio [OR] = 0.74, 95% confidence interval (CI): 0.66-0.82).The association of BLK in Chinese SLE patients was consistent with a dominant model (P = 8.88 x 10(-9), OR = 0.69, 95% CI: 0.61-0.79).
|
20130895 |
2010 |
rs2248932
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
|
18204446 |
2008 |
rs2248932
|
|
|
0.720 |
GeneticVariation |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
rs2248932
|
|
|
0.720 |
GeneticVariation |
BEFREE |
On the assessment of available evidence, the authors concluded that moderate evidence exists for an association between the BLK rs13277113, rs2248932 variants and SLE.
|
21152986 |
2011 |
rs146505280
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs2736345
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |